New roles of STAT5 factors in chronic myeloid leukemia cell maintenance
نویسندگان
چکیده
" Strive not to be a success, but rather to be of value " Albert Einstein appris à être sérieuse, persévérante, intègre, attentive aux opportunités de la vie et qui m'ont toujours encouragée à partir et faire mes choix professionnels.
منابع مشابه
STAT5 signaling is required for the efficient induction and maintenance of CML in mice.
The role of signal transducers and activators of transcription 5 (STAT5) in chronic myelogenous leukemia (CML) is controversial. To clarify the role of STAT5 signaling in P210(BCR/ABL) leukemogenesis, P210 was introduced into primary murine STAT5A-deficient (STAT5A(-/-)) bone marrow (BM) cells, which, unlike STAT5A/5B double knockout BM cells, have no major intrinsic hematopoietic defects. Inte...
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Signal transducers and activators of transcription (Stats) play central roles in the conversion of extracellular signals, e.g., cytokines, hormones and growth factors, into tissue and cell type specific gene expression patterns. In normal cells, their signaling potential is strictly limited in extent and duration. The persistent activation of Stat3 or Stat5 is found in many human tumor cells an...
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